1. Go to the Profiling section
2. Click the New button and gave the name of the profiler (in my case it is "Custom Structure similarity profiler")
3. Select Linear type and confirm
4. Rename the category or leave it as it is. It is up to you.
5. Click ADD in the right-menu buttons
6. Select Similarity Query
7. In the Expression field, specify the threshold of similarity (e.g. >=1%)
8. Go to Options and specify the formula, atom characteristics, etc.
9. The most important thing is to add the structure of your target chemical (just past the SMILES in the blank field or draw it by the Define button). This will be the chemical that will be compared with each chemical available on the data matrix. Confirm by OK button
11. The target chemical appears on the right
12. Finally click the Save Scheme button and close the window
