1. Open an Excell file and put the available information (columns for CAS/Name/SMILES are needed)
![](https://s3.amazonaws.com/cdn.freshdesk.com/data/helpdesk/attachments/production/16034354956/original/RH4ULqzfE325YyaWNIHhewKpRlK31S-C8w.png?1554374528)
2. Select and copy the three columns with ID information
![](https://s3.amazonaws.com/cdn.freshdesk.com/data/helpdesk/attachments/production/16034354955/original/hTa_HZhZ7QpUBArti9nPi3Vl30Ltar5hlw.png?1554374528)
3. Open Notepad and paste the copied information
4. Go to File >> Save as..
![](https://s3.amazonaws.com/cdn.freshdesk.com/data/helpdesk/attachments/production/16034354954/original/s7hLIjV0Ksr9vJr_hQzW9stMFAj2_ABkRw.png?1554374528)
5. Select the location where the file will be saved
6.Type a name of the file with smi extension. For example if you file is named "My_chemicals_list", then you should type "My_chemicals_list.smi"
7. Select All types from the drop-down menu and save the file.
![](https://s3.amazonaws.com/cdn.freshdesk.com/data/helpdesk/attachments/production/16034355463/original/mysCNZHAZYgBb2zdEu14NtSLu17MYwzNfA.png?1554374841)
Now the .smi file is ready and you can load it into the Toolbox.