When creating a new document in Toolbox v.4 you can choose to ignore or account stereo (Figure 1). This functionality refers to the same 2D/2.5 D mode available in TB 3.4 (main option menu) accounting for stereo information of chemicals. The main difference is that in TB 4.0 this functionality is available per document, which means that stereo could be accounted for or not for each separate document. The latter avoids the need of restarting the system as in TB 3.4.
Figure 1